A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family
نویسندگان
چکیده
منابع مشابه
A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family.
The BAR (Bin/amphiphysin/Rvs) domain defines an emerging superfamily of proteins implicated in fundamental biological processes by sensing and inducing membrane curvature. We identified a novel autoregulatory function for the BAR domain of two related GAPs' (GTPase-activating proteins) of the GRAF (GTPase regulator associated with focal adhesion kinase) subfamily. We demonstrate that the N-term...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2008
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20081535